2026 Australian Open

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Novak Djokovic vs Lorenzo Musetti Tips, Prediction & Live Stream - Djokovic set for 10th win over Musetti

Andrew Hendrie

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Last updated: Tue 27 Jan 2026 22:36

Andrew Hendrie 27 Jan 2026

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Novak Djokovic vs Lorenzo Musetti predictions for Wednesday's Australian Open quarter-final match
Djokovic has dominated this matchup, winning nine of the 10 previous meetings
Musetti has never beaten a top five player at a major, Djokovic predicted to prevail in four or five sets
The match is scheduled to start around 3.00pm AEDT on Wednesday January 28

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Novak Djokovic (Photo by Getty Images)

Novak Djokovic vs Lorenzo Musetti Tips, Prediction & Live Stream

Novak Djokovic continues his pursuit of a record 25th Grand Slam title when he comes up against familiar foe Lorenzo Musetti in the Australian Open quarter-finals on Wednesday afternoon.

Novak Djokovic vs Lorenzo Musetti Tips, Prediction & Live Stream
Djokovic vs Musetti Stats & Trends
Djokovic vs Musetti Head To Head
Novak Djokovic Form Analysis
Lorenzo Musetti Form Analysis
Djokovic vs Musetti Live Stream

Ten-time Australian Open champion Djokovic has enjoyed the smoothest possible passage into the last eight in Melbourne, advancing without relinquishing a single set and enjoying a walkover in the R16 when Jakub Mensik withdrew. The 38-year-old couldn't have hoped for a better opening week and now the real challenge begins. Meanwhile, Musetti continues to prove he is far more than a clay court specialist, backing up his US Open quarter-final run by replicating the feat in Melbourne, dominating Taylor Fritz in straight sets in the previous round.

However, Musetti has never defeated a top five player at a major and he's also got a terrible record against Djokovic. The primary reason for this is the backhand to backhand exchanges. While Musetti's single-hander is nice to watch, it just doesn't match up well with arguably the greatest two-handed backhand the sport has ever seen. Djokovic is just too solid off that wing and breaks down Musetti's one-hander throughout the course of a match. His record against one-handers says it all. This is a big step up for Djokovic than his previous matches and I think Musetti is playing well enough to win at least one set, but have to side with the 10-time champion here.

Djokovic vs Musetti Stats & Trends

Djokovic has won nine of the 10 meetings between the pair
Two of their three Grand Slam meetings have seen Over 3.5 sets
Musetti is 0-7 vs top five players at Grand Slams
Djokovic is 8-0 in his last eight Australian Open quarter-finals
Djokovic hasn't lost to a player with a single-handed backhand at a Grand Slam since the 2019 US Open (retired vs Wawrinka)
Djokovic has seen Over 3.5 sets in his last two Grand Slam matches vs top 10 players outside of Sinner & Alcaraz

Djokovic vs Musetti Head To Head

Djokovic leads 9-1, winning their most-recent clash in the final of Athens late last year in a deciding set.

Year / Event	Winner	Score
2025 – Hellenic Championship (Athens Final)	Novak Djokovic	4–6, 6–3, 7–5
2025 – Miami Open (Round of 16)	Novak Djokovic	6–2, 6–2
2024 – Olympics (Paris Semifinal)	Novak Djokovic	6–4, 6–2
2024 – Wimbledon (Semifinal)	Novak Djokovic	6–4, 7–6, 6–4
2024 – French Open (Round of 32)	Novak Djokovic	7–5, 6–7, 6–2, 6–3
2024 – Monte Carlo Masters (Round of 16)	Novak Djokovic	7–5, 6–3
2023 – Monte Carlo Masters (Round of 16)	Lorenzo Musetti	4–6, 7–5, 6–4
2022 – Paris Masters (Round of 16)	Novak Djokovic	6–0, 6–3
2022 – Dubai Tennis Championships (Round of 32)	Novak Djokovic	6–3, 6–3
2021 – French Open (Round of 16)	Novak Djokovic	6–7, 6–7, 6–1, 6–0, 4–0 ret.

Novak Djokovic Form Analysis

2026 Record: 4-0
Australian Open Record: 103-10
Grand Slam Record: 401-55
Current Ranking: No. 4
Career-High Ranking: No. 1 (2011)

Road to Australian Open quarter-finals

Round	Opponent	Score
1st Round	Pedro Martínez	6–3, 6–2, 6–2
2nd Round	Francesco Maestrelli	6–3, 6–2, 6–2
3rd Round	Botic van de Zandschulp	6–3, 6–4, 7–6(4)
4th Round	Jakub Menšík	Walkover

While it was a disappointing 2025 for Djokovic's lofty standards, he still managed to win two ATP titles and make the semi-finals of all four Grand Slams, maintaining a top five ranking despite playing a limited schedule.

Obviously the majors are Djokovic's primary focus and he couldn't have asked for a better start to his Australian Open title quest this tournament.

Djokovic swept aside Pedro Martinez and qualifier Francesco Maestrelli without dropping more than three games in a set to reach the third round.

The 38-year-old was challenged more by the dangerous Botic Van De Zandschulp, but he held firm during a tough third set to edge out the tiebreak. Djokovic then benefitted from a withdrawal by Jakub Mensik (the man who beat him in last year's Miami final) to reach the quarter-finals without dropping a set.

Lorenzo Musetti Form Analysis

2026 Record: 7-1
Australian Open Record: 7-4
Grand Slam Record: 36-19
Current Ranking: No. 5
Career-High Ranking: No. 5

Road to Australian Open quarter-finals

Round	Opponent	Score
1st Round	Raphael Collignon	6–4, 7–6(3), 7–5 3-2 RET
2nd Round	Lorenzo Sonego	6–3, 6–3, 6–4
3rd Round	Tomas Machac	5–7, 6–4, 6–2, 5–7, 6–2
4th Round	Taylor Fritz	6–2, 7–5, 6–4

Musetti propelled himself into the top 10 following a stellar clay swing last season, but he's proven he can play superb tennis on grass and hardcourt, recently cracking the top five and having a chance of ending this tournament in the top three.

The Italian began the year in promising fashion as he advanced to the final in Hong Kong - however, his wait for a first ATP title since 2022 continued as he was defeated by Alexander Bublik.

Not to be deterred, Musetti has produced some fantastic tennis at this Australian Open against some difficult and in-form opponents to make a first quarter-final in Melbourne.

Musetti survived the extremely dangerous Raphael Collignon in the opening round before taking out last year's Australian Open quarter-finalist Lorenzo Sonego in straights. The 23-year-old then outlasted Adelaide champion Tomas Machac in five sets before crushing fellow top 10 player Taylor Fritz in straights, serving 13 aces and firing 33 winners.

Djokovic vs Musetti Live Stream

Watch and bet on Novak Djokovic vs Lorenzo Musetti live Australian Open tennis.

You can watch and bet on the match live at Unibet > Tennis > Australian Open with the action available to stream on desktop and mobile.

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Verdict

Novak Djokovic v Lorenzo Musetti

Musetti can push Djokovic, but over the course of five sets, the Serbian is tipped to prevail and continue his dominant record over the Italian.

Over 3.5

Total Sets

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Djokovic & Yes

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