Alexander Zverev vs Lorenzo Musetti Tips, Prediction & Live Stream - Musetti aims for fourth top 10 win of 2025

Zverev has been under-performing since the Australian Open final, but is hoping to find his best tennis once again in Rome, where he is a two-time champion and a former runner-up. However, Zverev hasn't won a completed knockout match against a top 10 player since the 2024 French Open and he will have to overcome that hurdle on Wednesday night if he wants to keep his Rome title defence alive.

Musetti has transformed into a genuine elite player of the game over the last couple of months, peaking at a current career-high of No. 9 in the world. The Italian has won 21 of his last 25 matches on clay and furthermore, tasted victory in his last two meetings with Zverev - including on his way to the bronze medal at the Paris Olympics last year. All things considered, Musetti offers good value in front of a home crowd as the underdog here.

Musetti leads 2-1 and 2-0 in completed matches, prevailing 26 76(5) 64 in the 2024 Vienna quarter-finals and 7-5 7-5 in the Paris Olympics last eight. Musetti will now be aiming for a third straight quarter-final victory over Zverev in Rome.

Zverev comes into this clash with a 24-8 record on the season as he continues to search for his best form.

Much has been documented about Zverev's struggles following another Grand Slam final defeat to Jannik Sinner at the Australian Open, with the German failing to take advantage of the Italian's absence on tour over the last three months as the No. 1 ranking was there for the taking.

Although he was able to capture the title at home in Munich, Zverev still didn't produce his best level and was subsequently upstaged by Francisco Cerundolo in the Madrid Masters R16.

However, perhaps a return to Rome will provide another spark for Zverev as it has done in the past - he hasn't dropped a set en route to the quarter-finals, easing past Camilo Ugo Carabelli, Vilius Gaubas and Arthur Fils.

Musetti arrives at this contest with a 19-6 record on the season, taking his game to another level since the start oft he European clay swing.

The Italian has impressed with a maiden Masters 1000 final appearance at Monte Carlo, where he led Carlos Alcaraz by a set, backing it up with a run to the semi-finals in Madrid.

Coming into his home tournament in Rome with increased pressure and expectation as a top 10 player, Musetti has handled the occasion superbly, advancing to the quarter-finals without dropping a set in victories over Otto Virtanen, Brandon Nakashima and Daniil Medvedev.

The win over Medvedev was especially memorable, with Musetti coming from from an-almost three-hour rain delay to win one point in a 7-5, 6-4 victory.