UEFA Champions League 2026/27

Real Madrid vs RB Leipzig UEFA Champions League Tips & Prediction - Leipzig in danger of another big defeat

Andrew Hendrie

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Last updated: Wed. 21 Oct. 2026 02:33

Andrew Hendrie 1 hour ago

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Real Madrid vs RB Leipzig predictions for Wednesday's Champions League game
Real on fire at home, winning six from six - plenty of goals expected
Defence still vulnerable for Los Blancos, so Leipzig tipped to score in defeat
The game is scheduled for kick off at 6.00am AEDT on Thursday October 22

Real Madrid vs RB Leipzig UEFA Champions League Tips & Prediction

Real Madrid are tipped to score 3+ goals in a big win over RB Leipzig on Matchday 3 of the Champions League on Wednesday night at the Bernabéu.

Real Madrid vs RB Leipzig UEFA Champions League Tips & Prediction
Real Madrid vs Leipzig Stats & Trends
Real Madrid Form Analysis
Real Madrid Team News
RB Leipzig Form Analysis
RB Leipzig Team News

Real have won all six of their home games this season in Jose Mourinho's return to the club, while they've also been victorious in both Champions League fixtures this term - Los Blancos really shouldn't have any trouble with a Leipzig side coming off a 6-1 thrashing by Bayern and who have lost nine of their last 12 games in this competition.

The goals should flow and Real are backed for at least three, while Leipzig can get on the scoresheet in defeat - they've found the back of the net in all but one game in all competitions this season, while Real's defence remains vulnerable.

Not much value in backing Kylian Mbappe for goals, but you can get $2.40 for the superstar striker to have 4+ shots on target - something he's done in both CL appearances this term.

Recent trends also back a mini 2-leg SGM featuring Jude Bellingham and Antonio Nusa - see stats below.

Real Madrid vs Leipzig Stats & Trends

Real have won all six of their home games in all comps this season
Real have scored 3+ goals in four of those six wins
Leipzig have scored in seven of their last eight games
Real have conceded 1+ goal in six of their last seven games
Kylian Mbappe has registered 4+ shots on target in both CL games this season
Jude Bellingham has won 2+ fouls in eight straight games
Antonio Nusa has registered 2+ shots in eight of his last nine games

Real Madrid Form Analysis

It's been far from smooth sailing this season for Real, but they have a perfect record at home and in the Champions League.

Real were outplayed for large portions of both of their CL games against Inter and Roma, coming from behind to record 2-1 and 4-3 victories respectively. Their win in the Italian capital was a wild affair, with Los Blancos scoring from three corners in seven minutes to overturn a 3-1 deficit with 10 minutes remaining.

Mourinho's side enjoyed a far more comfortable victory at the weekend, easing past Sevilla 4-1 to be six points adrift of Barcelona ahead of this week's blockbuster El Clasico.

Real Madrid Team News

Mbappe scored a brace in the win over Sevilla, improving his tally to 11 goals in as many games this term, while Yan Diomande had more impact, scoring and providing an assist for Arda Guler's opener.

Rodrygo (knee), Ferland Mendy (hip) and Raul Asencio (leg) remain sidelined, while Vini Jr should come into the starting side for Endrick. Fede Valverde could move back to his regular midfield role, with Denzel Dumfries coming in at right back.

Real Madrid Possible Starting XI (4-2-3-1): Thibaut Courtois; Denzel Dumfries, Ibrahima Konaté, Antonio Rüdiger, Álvaro Carreras; Federico Valverde, Aurélien Tchouaméni; Yan Diomande, Jude Bellingham, Vinicius Junior; Kylian Mbappé

RB Leipzig Form Analysis

Not the best start to the season for Leipzig, who are outside the top six in the Bundesliga following last weekend's 6-1 humbling at Bayern.

That snapped a run of good results, including a 6-0 hammering of their own over Eintracht Frankfurt and a 1-0 win over PSV on Matchday 2.

It was a much needed Champions League win, with Leipzig suffering a 4-1 loss away to Como on Matchday 1. The German club have struggled in this competition, winning just two of their last 12 outings.

RB Leipzig Team News

Nusa has been impressive to start the season, registering four goals and three assists in nine appearances - he'll be the main threat for Leipzig in the final third.

Christoph Baumgartner (hamstring) and Assan Ouedraogo (shoulder) are out injured.

Leipzig Possible Starting XI (4-2-3-1): Maarten Vandevoordt; Ridle Baku, Willi Orbán, Castello Lukeba, David Raum; Neil El Aynaoui, Nicolas Seiwald; Brajan Gruda, Christopher Nkunku, Antonio Nusa; Romulo