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NFL Week 2 Best Bets - Value on the Slate

Ryan Tucker

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Last updated: Thu 17 Sep 2026 13:21

Ryan Tucker 1 hour ago

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Kenneth Walker III tipped to exceed 79.5 rushing yards vs Colts' weak run defense.
Derrick Henry poised for 2+ touchdowns facing Saints' porous D; Giants/Rams likely to go over 48.5 points.
Patriots expected to struggle offensively, unlikely to top 23.5 points vs Steelers.

NFL Week 2 Best Bets - 2026 Season Opener Edition

Three weeks of sample size is one week better than nothing and Week 1 handed us enough data to find real edges in Week 2. Here's where the numbers point.

NFL Week 2 Best Bets - 2026 Season Opener Edition
Indianapolis Colts @ Kansas City Chiefs
New Orleans Saints @ Baltimore Ravens
New York Giants @ Los Angeles Rams
Pittsburgh Steelers @ New England Patriots

Note: All odds correct at time of publishing

Indianapolis Colts @ Kansas City Chiefs

Pick: Kenneth Walker III over 79.5 Rush Yards

Walker over 79.5Rush Yards$1.86 Bet Here

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Kenneth Walker ran for 173 yards at 7.5 per carry in his KC debut, and the Colts just gave up 144 yards at 6.0 per carry to Derrick Henry, plus 40 more and a TD on the ground to Lamar Jackson. Indianapolis's run defense didn't just struggle in Week 1, it got carved up from every direction. Walker now gets to attack it fresh off a performance that announced his arrival in the loudest possible way.

On the other side, Indy's quarterback Anthony Jones faces a KC defense that held Denver to 10 points, 176 yards, and stopped 10 of 12 third-down attempts. The Colts OL is already leaking, with LT Bernard Reiman posting a 23% pressure rate. This matchup has KC dominance written all over it.

New Orleans Saints @ Baltimore Ravens

Pick: Derrick Henry 2+ Touchdowns

Derrick Henry 2+Touchdowns$3.10 Bet Here

18+ only. T&Cs apply

The Ravens put up 41 points and 500+ yards in Week 1, went 5-for-5 in the red zone, and generated a 50.9% pressure rate. Now they get a Saints defense that allowed Jahmyr Gibbs 156 yards at 5.4 per carry with two TDs, and Derrick Henry is coming off 144 yards, 3 TDs, and 6.0 YPC of his own. Saints run defence is a sieve, and Baltimore's ground game is a wrecking ball.

New Orleans also turned the ball over three times in Week 1 and allowed five sacks. Zay Flowers is questionable with a hamstring injury, which removes the one defensive assignment that might have complicated Baltimore's week. The Ravens don't need any extra help. They're taking it anyway.

New York Giants @ Los Angeles Rams

Pick: Over 48.5 Game Total

Over 48.5Game Total$1.90 Bet Here

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The Rams put up one of the ugliest offensive performances of Week 1 anywhere in the league: 7 points, 155 Stafford yards, 0 TDs, 1 INT, 2-of-9 on third down. Their pass protection gave up a 41% pressure rate, with RG Kevin Dodson allowing pressure on nearly 18% of his snaps. Miles Garrett is out with a knee injury, leaving the Rams' pass rush in real doubt.

Meanwhile, the Giants arrived in Week 2 with Dart posting a 130+ passer rating and three TDs, Neighbors and Skattabo both healthy and contributing, and a defence that held Dallas to 20 points and under 5 yards per play. The Giants are the form team here. The Rams need to rediscover their offence from scratch in a matter of days. That's a tough ask.

Pittsburgh Steelers @ New England Patriots

Pick: Patriots Under 23.5 Team Total

Patriots Under 23.5Team Total$1.90 Bet Here

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A.J. Brown is confirmed out. TreVeyon Henderson's status is uncertain. Drake Maye threw three interceptions and scored 10 points on barely 4 yards per play against Seattle in Week 1. TJ Watt, fresh off a pick-six and two sacks, now gets to line up against Morgan Moses. Pittsburgh's defence doesn't need much of an invitation.

The Steelers' offence wasn't spectacular in Week 1 either with 13 points and 3-of-13 on third down, but they don't need to be spectacular here. They need to be competent against a New England offence missing key weapons and still working out its identity. The Steelers win this one by doing less wrong.