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San Francisco 49ers at Indianapolis Colts NFL Week 16 Tips & Predictions - Niners Set to Steam into Playoffs

ryan-tucker
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Last updated: Thu 18 Dec 2025 09:16

The San Francisco 49ers are primed to strengthen their playoff position with a win over the Indianapolis Colts in NFL Week 16. The 49ers have been formidable, winning their last four games with Brock Purdy leading an impressive offensive charge. In contrast, the Colts have struggled post their early-season success, dropping their last four games. The 49ers are predicted to win by more than one score, with the Colts struggling to exceed 20 points. Key players like Brock Purdy and George Kittle are expected to have outstanding performances.

Ryan Tucker 18 Dec 2025
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  • San Francisco 49ers at Indianapolis Colts Expert NFL Tips for Week 16
  • Kick Off is at 12:15 PM AEDT at Lucas Oil Stadium
  • 49ers on a 4-game winning streak averaging 31 pts/game.
  • Colts falter with 4 consecutive losses, averaging <20 pts.
  • 49ers favored to win; Purdy & Kittle expected to excel.
San Francisco 49ers at Indianapolis Colts NFL Week 16

San Francisco 49ers at Indianapolis Colts NFL Week 16 Tips & Predictions


San Francisco have a buffer over teams in the NFC North chasing them for their play-off spot, but another win here will move them a step closer to football in January. 

The 49ers piled on the points last weekend against Tennessee, in fact over their last 4 games, all wins, they have averaged 30+ pts. Brock Purdy has been electric, putting to bed the rumours from earlier in the season that the team might want to move him on. He will be the key player in this matchup against a Colts defence ranked 31st in opponent Pass Yards.

For Indianapolis, unfortunately this is likely to end up being a season of what could have been. An 8-2 record heading into their week 11 bye, the road seemed to be paved with gold. Then the wheels fell off, 4 straight losses, no scores higher than 20 pts and their reformed star at QB gone for the season. 

This team may still limp into the playoffs thanks to their amazing start and the relative poor records of other teams in the conference, but they won’t hang around long. The high scoring games of September and October are a distant memory, now they are just trying to cling to relevancy.

Take the Niners to win by more than one score and the Colts team total to stay under 20. Brock Purdy will lead the team through the air, take his Passing Over 244.5 and George Kittle to get into the endzone.

  • The Colts have lost 4 straight, not scoring more than 20 points on all 4 occasions. 
  • San Francisco are ranked 11th in scoring defence, restricting teams to an average of 20.9 per game.
  • Indianapolis are ranked 31st in opponent pass yards, Brock Purdy has busted poor secondaries this season, he threw 295 yds last week.
  • George Kittle has 6 receiving TD’s this season and has a 20% Red Zone Target share.

Head to Head Record


All Time Record


Indianapolis Colts lead all-time series 27-18.

Most Recent Matchup


DateResult
Oct 24, 2021
IND 30 @ SFO 18

Statistical Rankings


StatSFOIND
Points Scored/Game24.6 (11th)28.0 (6th)
Points Allowed/Game20.9 (11th)21.6 (12th)
Pass Yds/Game246 (4th)229 (9th)
Rush Yds/Game101 (25th)128 (6th)
Def. Pass Yds/Game227 (22nd)247 (31st)
Def. Rush Yds/Game106 (12th)95 (6th)

San Francisco 49ers Form


San Francisco extended their record to 10-4 last weekend with a solid 37-24 win over the Tennessee Titans. Despite the fantastic record, they are still 3rd in their division and risk dropping out of the playoffs if they don’t win out. 

They have now won 4 straight games averaging 31 pts per game on offence while allowing just 15.75 pts to their opponents through the streak. Brock Purdy finished with a 140.3 rate last weekend, passing for 295 yards and 3 TD’s without giving up the ball.

The defence probably should not have allowed 24 pts to the Titans but when the scoring is flowing at one end, it is difficult to restrict entirely at the other. They will need to tighten up their 12th ranked rush defence against the Colts this weekend.


Team Table
TeamRecordATSO/UAwayHome
San Francisco logo SF10-4-09-5-08-5-16-2-04-2-0

Indianapolis Colts Form


The Colts brought in Grandpa Rivers last weekend for their matchup against the Seattle Seahawks and while the old boy did look a little rusty, they weren’t terrible. They still ended up losing 18-16 but there was only 1 TD in the game, thrown by Philip Rivers in the 2nd quarter.

Rivers had a 73.1 rate with 120 yards from 18 completions for 1 TD and 1 INT. He was sacked once in the game. On the other end Sam Darnold was not brought down but also didn’t connect with any receivers in the end zone, only the 4th time this season a team has held him quiet. 

Indianapolis have the 12th ranked scoring defence and the 6th ranked rush defence but are 31st against the pass allowing 247 yards per game.


Team Table
TeamRecordATSO/UAwayHome
Indianapolis logo IND8-6-08-5-17-7-02-5-06-1-0

San Francisco 49ers vs Indianapolis Colts Frequently Asked Questions

What time does San Francisco 49ers vs Indianapolis Colts start?

Kickoff between San Francisco 49ers vs Indianapolis Colts is at 12:15 PM AEDT, Tuesday

What channel is San Francisco 49ers vs Indianapolis Colts on?

You can watch San Francisco 49ers vs Indianapolis Colts on DAZN

Verdict

Take the Niners to win by more than one score and the Colts team total to stay under 20. Brock Purdy will lead the team through the air, take his Passing Over 244.5 and George Kittle to get into the endzone.
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SF 49ers -6
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