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Indianapolis Colts @ San Francisco 49ers Tips & Live Stream - Colts to beat the 49ers

  • Indianapolis Colts @ San Francisco 49ers tips for Monday’s NFL match
  • Both teams have won two games this season
  • The Colts are in second spot of the AFC South
  • The 49ers are in third place in the NFC West
  • Match Preview, predictions and stats 
Colts to get third win of season
Colts to get third win of the season (credit: Getty Images )
Fraser Stewart 21 Oct 2021
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Indianapolis Colts @ San Francisco 49ers Tips 

The Colts needed a response after an overtime loss to the Baltimore Ravens in week 5 of the season and they got just that when they defeated the Houston Texans in week 6. 

After losing to the Arizona Cardinals in week 5 of the season, the 49ers had a bye week.

  • Colts have beaten the 49ers for four consecutive games from 2005 to 2017
  • Colts running back Jonathan Taylor is ranked fifth in the NFL for offensive rushing yards with 472
  • Colts have a turnover ratio of +7 ranking them fourth in the league


Over the last 10 games dating back to 1972, these two sides are split with five wins each. 

However, looking at the past five matches, the Colts have won four of the five matches which included four wins in a row from 2005 to 2017. 

The Colts defeated the 49ers in the last meeting as they claimed a 26-23 overtime win back in 2017. 

Indianapolis Colts Form 

The Indianapolis Colts didn’t start the season so well, going 0-3 in the first three weeks as they lost to the Seattle Seahawks in week 1, Los Angeles Rams in week 2 and the Tennessee Titans in week 3. 

The Colts then finally got their first win of the season in week 4, when they defeated the Miami Dolphins 27-17, but had to wait two weeks for their second as they defeated the Texans 31-3 to give them a 2-4 win-loss record. 

Indianapolis Colts Team News 

T.Y. Hilton, Tyquan Lewis, Braden Smith, Kemoko Turay, Rock Ya-Sin and Jordan Wilkins all did not participate in the team’s Wednesday training session. 

Julian Blackmon and Andrew Sendejo both were on limited duties. 

San Francisco 49ers Form 

The 49ers started the new season in great form, going 2-0 following back-to-back wins in week 1 and week 2 over the Detroit Lions and the Philadelphia Eagles respectively. 

However, they haven’t registered a win since as they have suffered three successive defeats to the Green Bay Packers, Seattle Seahawks and the Arizona Cardinals. 

The 49ers return from the bye week hoping that the mini break can restart their season. 

San Francisco 49ers Team News 

Javon Kinlaw, Trey Lance and Trent Williams did not participate in the team’s training session on Wednesday. 

Quarterback Jimmy Garoppolo and Marcell Harris were both on limited duties. K’Waun Williams was at full training. 

Indianapolis Colts @ San Francisco 49ers FAQs 

Where can I watch Indianapolis Colts @ San Francisco 49ers? 

Check out our live stream calendar of where you can watch Indianapolis Colts @ San Francisco 49ers. 

What time does the Indianapolis Colts @ San Francisco 49ers start? 

The game between Indianapolis Colts @ San Francisco 49ers starts at 11.20am AEST on Monday October 25.



While both teams have two wins against their names, the Colts look like they are finally ready to take on the rest of the season. Carson Wentz is also starting to play some good football as he threw two touchdown passes and threw 223 yards in their win over the Texans.

Best Bet: Indianapolis Colts Moneyline $2.71 at Sportsbet - 3 Units

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IND Colts @ SF 49ers